|
Symbol Name ID |
Stat4
signal transducer and activator of transcription 4 MGI:103062 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgM level |
Leukopenia |
Keratoconjunctivitis sicca |
Pericarditis |
Lymphadenopathy |
Splenomegaly |
Celiac disease |
Gastrointestinal inflammation |
Hepatitis |
Subacute progressive viral hepatitis |
Iridocyclitis |
Epididymitis |
Lupus nephritis |
Nephritis |
Abnormality of the immune system |
Erythema nodosum |
Discoid lupus rash |
Malar rash |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Autoimmunity |
Antimitochondrial antibody positivity |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Systemic lupus erythematosus |
Recurrent fungal infections |
Onychomycosis |
| Disease(s) Associated with STAT4 | |||||||||||||||||||||||||||||||||||
| Behcet's disease | |||||||||||||||||||||||||||||||||||
| hepatocellular carcinoma | |||||||||||||||||||||||||||||||||||
| IgA glomerulonephritis | |||||||||||||||||||||||||||||||||||
| primary biliary cholangitis | |||||||||||||||||||||||||||||||||||
| Sjogren's syndrome | |||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus |
| Mouse Phenotypes | abnormal T cell proliferation |
abnormal CD4-positive T cell differentiation |
abnormal lymphocyte physiology |
abnormal NK cell physiology |
abnormal T-helper 1 physiology |
abnormal T-helper 2 physiology |
decreased circulating interferon-gamma level |
increased circulating interleukin-12 level |
decreased circulating interleukin-2 level |
abnormal cytokine secretion |
decreased interferon-gamma secretion |
increased interleukin-4 secretion |
decreased susceptibility to autoimmune diabetes |
abnormal inflammatory response |
increased susceptibility to bacterial infection |
increased susceptibility to bacterial infection induced morbidity/mortality |
|
| Availability | Mouse Genotype | ||||||||||||||||
| Stat4ity14/Stat4ity14 | |||||||||||||||||
| Stat4tm1Gru/Stat4tm1Gru | |||||||||||||||||
| Stat4tm1Jni/Stat4tm1Jni | |||||||||||||||||
| Stat4ity14/Stat4tm1Gru | |||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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